BI 831266( BI831266 )

Catalog No. M16845 CAS No. 958227-46-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BI 831266
Note

Research use only, not for human use.
Brief Description

BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.
Description

BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM; inhibits the proliferation of human non-small cell lung cancer (NSCLC), pancreatic cancer, and prostate cancer cell lines (H460 tumor cell proliferation inhibition IC50=11 nM); causes tumor regression and growth inhibition in in murine xenograft tumor models (HCT 116 colon carcinoma, BxPC3 pancreatic adenocarcinoma, and NCI-H460 NSCLC).Solid Tumors Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

BI831266
Pathway

Cell Cycle/DNA Damage
Target

Aurora Kinase
Recptor

Aurora Kinase
Research Area

Cancer
Indication

Solid Tumors

CAS Number

958227-46-8
Formula Weight

528.098
Molecular Formula

C27H38ClN7O2
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(N(C)C1CCN(C)CC1)C2=CC=C(NC3=NC=C(Cl)C(N[C@H]4[C@@H](C(NC(C)C)=O)CCC4)=N3)C=C2
Chemical Name

4-((5-chloro-4-(((1R,2S)-2-(isopropylcarbamoyl)cyclopentyl)amino)pyrimidin-2-yl)amino)-N-methyl-N-(1-methylpiperidin-4-yl)benzamide

1. Dittrich C, et al. Invest New Drugs. 2015 Apr;33(2):409-22.

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